The James Cotton Blues Band was an influential American blues band led by James Cotton, a renowned harmonica player. Formed in the mid-1960s, the band was known for its eclectic style, blending elements of traditional blues with rock and jazz. Cotton's virtuosic harmonica playing was a signature element of the band's sound, underpinning their most notable works such as "High Compression" and "100% Cotton". The band's energetic performances and innovative arrangements significantly contributed to the development and expansion of electric blues music.