The Soul Sisters were a significant duo in the 1960's R&B and soul music scene, consisting of members Thresia Cleveland and Ann Gissendanner. They are best known for their hit "I Can't Stand It," which climbed to number 20 on the Billboard R&B chart in 1964. The duo is recognized for their blend of gospel and soulful harmonies, combined with powerful, emotive vocals. Their influence on the female soul genre has been noted as they broke ground in a predominantly male industry.